ADH5 Matched Antibody Pair (027) (APMAB-027LY)

Name: ADH5 Matched Antibody Pair (027)
SKU: APMAB-027LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-ADH5 polyclonal antibody, 100 ug

Detection Antibody

Anti-ADH5 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

Alternative Names

Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide; Glutathione-Dependent Formaldehyde Dehydrogenase; S-(Hydroxymethyl)Glutathione Dehydrogenase; Alcohol Dehydrogenase Class Chi Chain; Alcohol Dehydrogenase Class-III; S-Nitrosoglutathione Reductase; Formaldehyde Dehydrogenase; EC 1.1.1.1; GSH-FDH; FALDH; ADHX; FDH;

Entrez Gene ID

128

UniProt ID

P11766

More Infomation

References

Zhao, J., Wei, Q., Gu, X. R., Ren, S. W., & Liu, X. N. (2020). Alcohol dehydrogenase 5 of Helicoverpa armigera interacts with the CYP6B6 promoter in response to 2‐tridecanone. Insect science, 27(5), 1053-1066.

Oka, Y., Hamada, M., Nakazawa, Y., Muramatsu, H., Okuno, Y., Higasa, K., ... & Ogi, T. (2020). Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome. Science Advances, 6(51), eabd7197.

Suo, C., Yang, Y., Yuan, Z., Zhang, T., Yang, X., Qing, T., ... & Ye, W. (2019). Alcohol intake interacts with functional genetic polymorphisms of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) to increase esophageal squamous cell cancer risk. Journal of Thoracic Oncology, 14(4), 712-725.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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