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UMOD Matched Antibody Pair (1294) (APMAB-1294LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-UMOD monoclonal antibody, 100 ug
Detection Antibody
Anti-UMOD Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Alternative Names
Uromodulin; Tamm-Horsfall Urinary Glycoprotein; Uromucoid; THP; Uromodulin (Uromucoid, Tamm-Horsfall Glycoprotein); Tamm-Horsfall Glycoprotein; ADMCKD2;
Entrez Gene ID
7369
UniProt ID
P07911
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For research use only. Not intended for any clinical use.

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