WNT8B

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.

Wnt Family Member 8B

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process determination of dorsal identity Source:BHF-UCLBy Similarity
Biological Process gastrulation Source:BHF-UCLBy Similarity
Biological Process nervous system development Source:ProtInc1 Publication
Biological Process neuron differentiation Source:UniProtKB
Biological Process response to estradiol Source:BHF-UCL1 Publication
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Secreted, extracellular space, extracellular matrix

Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity).
Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.