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UCHL1

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Full Name
Ubiquitin C-Terminal Hydrolase L1
Function
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed:9774100, PubMed:8639624, PubMed:12408865, PubMed:23359680).
Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity).
The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865).
Biological Process
Biological Process adult walking behavior Source:Ensembl
Biological Process axon target recognition Source:Ensembl
Biological Process axonal transport of mitochondrion Source:Ensembl
Biological Process cellular response to xenobiotic stimulus Source:Ensembl
Biological Process eating behavior Source:Ensembl
Biological Process male germ cell proliferation Source:Ensembl
Biological Process muscle cell development Source:Ensembl
Biological Process negative regulation of MAP kinase activity Source:BHF-UCL1 Publication
Biological Process neuromuscular process Source:Ensembl
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:ParkinsonsUK-UCL1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process response to ischemia Source:Ensembl
Biological Process sensory perception of pain Source:Ensembl
Cellular Location
Cytoplasm
Endoplasmic reticulum membrane
About 30% of total UCHL1 is associated with membranes in brain.
Involvement in disease
Parkinson disease 5 (PARK5):
A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.
Spastic paraplegia 79, autosomal recessive (SPG79):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG79 is characterized by childhood onset blindness, cerebellar ataxia, nystagmus, dorsal column dysfunction, and spasticity with upper motor neuron dysfunction.
PTM
O-glycosylated.

Anti-UCHL1 antibodies

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Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig
Clone: CF465
Application*: ELISA, WB, IHC, IF
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 19G8
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 19E2
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 17E3
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 15C7
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14G3
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14D4
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13H8
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10G9
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10F11
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10A1
Application*: E, M
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB457A
Application*: ELISA, WB, ICC
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB79A
Application*: ELISA, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cattle, Horse, Mouse, Pig, Rat
Application*: IF, IHC, ICC, WB
Target: UCHL1
Host: Mouse
Specificity: Human
Clone: IHC647
Application*: IH
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: YK-3G8
Application*: E, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: UBCE-L1
Application*: P, WB
Target: UCHL1
Host: Mouse
Specificity: Human
Clone: S1
Application*: E, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: PASE/4LJ
Application*: C, P, WB
Target: UCHL1
Host: Mouse
Specificity: Human
Clone: P3D9AT
Application*: E, WB, IH
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GL-3/5E11
Application*: IH, IP, WB
Target: UCHL1
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: D8R2I
Application*: WB, IF
Target: UCHL1
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey, Hamster, Cattle, Dog, Pig, Horse
Clone: D3T2E
Application*: WB, P, IF, FC
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: BSB-46
Application*: C, P
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: AF3F8
Application*: WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: A98
Application*: ICC, IF, E, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9L604
Application*: E, IH
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 671108
Application*: WB, IH, IP
Target: UCHL1
Host: Mouse
Specificity: Human, Mouse
Clone: 3D9
Application*: E, WB, IH
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 35
Application*: E, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 3210
Application*: WB, IH
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B8-4D2
Application*: E, P, WB
Target: UCHL1
Host: Mouse
Specificity: Cattle, Human, Rat
Clone: 15H190
Application*: IF, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13k137
Application*: IF, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: 13k136
Application*: IF, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 12K192
Application*: IH, IP, WB
Target: UCHL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 104
Application*: WB, E, IP
Target: UCHL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 012
Application*: WB, E, IP
Target: UCHL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 011
Application*: WB, IP
Target: UCHL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 006
Application*: E
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 972106
Application*: WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 346CT2.2.1
Application*: E, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Cattle, Mouse, Pig, Rat
Clone: SPM574
Application*: E, IH, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Guinea pig, Pig, Rat
Clone: 10F343
Application*: E, IH, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Rat, Human, Pig
Clone: CBFYU-246
Application*: E, IF, WB, IC
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat
Clone: CBFYU-245
Application*: E, IF, IH, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: CBFYU-244
Application*: WB, IF
Target: UCHL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0258
Application*: WB, IP, P, F, IF
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Goat, Cat, Dog, Human
Clone: 346CT2.5.1
Application*: P, F, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: BH7
Application*: IF, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: BA0422
Application*: F, IF, C, P, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: UCHL1/775
Application*: P
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Sheep, Rabbit, Guinea pig, Dog, Pig, Zebrafish
Clone: 13C4
Application*: IC, IF, IH, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: BA0423
Application*: WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle, Pig
Clone: 31A3
Application*: P, WB
Target: UCHL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Sheep, Rabbit, Guinea pig, Cattle, Dog, Pig, Zebrafish
Clone: SPM575
Application*: IF, WB
Target: UCHL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0257
Application*: WB, IP, P, IC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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