Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

TYR

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq]
Full Name
tyrosinase (oculocutaneous albinism IA)
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity).
In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582).
Biological Process
Biological Process cell population proliferation Source:Ensembl
Biological Process eye pigment biosynthetic process Source:ProtInc1 Publication
Biological Process melanin biosynthetic process Source:CACAO1 Publication
Biological Process melanin biosynthetic process from tyrosine Source:ProtInc1 Publication
Biological Process pigmentation Source:GO_Central1 Publication
Biological Process response to blue light Source:UniProtKB1 Publication
Biological Process response to cAMP Source:Ensembl
Biological Process response to UV Source:Ensembl
Biological Process response to vitamin D Source:Ensembl
Biological Process thymus development Source:Ensembl
Biological Process visual perception Source:ProtInc1 Publication
Cellular Location
Melanosome membrane
Melanosome
Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Involvement in disease
Albinism, oculocutaneous, 1A (OCA1A):
An autosomal recessive disorder in which the biosynthesis of melanin pigment is absent in skin, hair, and eyes. It is characterized by complete lack of tyrosinase activity due to production of an inactive enzyme. Patients present with a life-long absence of melanin pigment after birth, and manifest increased sensitivity to ultraviolet radiation with predisposition to skin cancer. Visual anomalies include decreased acuity, nystagmus, strabismus and photophobia.
Albinism, oculocutaneous, 1B (OCA1B):
An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. It is characterized by partial lack of tyrosinase activity. Patients have white hair at birth that rapidly turns yellow or blond. They manifest the development of minimal-to-moderate amounts of cutaneous and ocular pigment. Some patients may have with white hair in the warmer areas (scalp and axilla) and progressively darker hair in the cooler areas (extremities). This variant phenotype is due to a loss of tyrosinase activity above 35-37 degrees C.
Topology
Lumenal: 19-476
Helical: 477-497
Cytoplasmic: 498-529
PTM
Glycosylated.

Anti-TYR antibodies

+ Filters
Loading...
Target: TYR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A2-F4
Application*: WB, E
Target: TYR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5533
Application*: WB, IH
Target: TYR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5534
Application*: E, IH, WB
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5535
Application*: WB
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5536
Application*: IH, WB
Target: TYR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5537
Application*: WB, IP, IF, E
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: OCA1/812
Application*: E, P, IF, IC, F
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM360
Application*: WB, F, E, IC, IF, IP, P, C, MC
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: T311
Application*: E
Target: TYR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5538
Application*: F, P, IF
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: TRSN1-1
Application*: P, IF, IC
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cat, Dog
Clone: CBYJT-5539
Application*: E, IC, IF, IH, WB
Target: TYR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cat, Dog
Clone: CBYJT-5540
Application*: E, IC, IF, IH, WB
Target: TYR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Cat
Clone: CBYJT-5541
Application*: E, IC, IF, P, WB
Target: TYR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-5542
Application*: F, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Online Inquiry