TDGF1

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

TDGF1 Gene(Protein Coding) Teratocarcinoma-Derived Growth Factor 1

GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714).
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).

Biological Process anatomical structure developmentIBA:GO_Central1 Publication
Biological Process anterior/posterior axis specification, embryoISS:UniProtKB
Biological Process anterior/posterior pattern specificationIBA:GO_Central1 Publication
Biological Process blood vessel developmentIBA:GO_Central1 Publication
Biological Process cell differentiationTAS:UniProtKB1 Publication
Biological Process cell migration involved in sprouting angiogenesisIMP:UniProtKB1 Publication
Biological Process cellular response to epidermal growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to fibroblast growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to hepatocyte growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to interferon-gammaIDA:UniProtKB1 Publication
Biological Process cellular response to interleukin-6IDA:UniProtKB1 Publication
Biological Process cellular response to tumor necrosis factorIDA:UniProtKB1 Publication
Biological Process determination of left/right symmetryIBA:GO_Central1 Publication
Biological Process embryo development ending in birth or egg hatchingTAS:UniProtKB1 Publication
Biological Process heart developmentIDA:UniProtKB1 Publication
Biological Process mammary gland developmentTAS:UniProtKB1 Publication
Biological Process morphogenesis of a branching structureTAS:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:UniProtKB1 Publication
Biological Process nodal signaling pathwayIBA:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylationIDA:UniProtKB1 Publication
Biological Process positive regulation of cell migrationIDA:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationIDA:MGI1 Publication
Biological Process positive regulation of endothelial cell migrationIDA:UniProtKB1 Publication
Biological Process positive regulation of MAP kinase activityIDA:MGI1 Publication
Biological Process positive regulation of MAPK cascadeIDA:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylationIDA:UniProtKB1 Publication
Biological Process regulation of signal transductionIDA:UniProtKB1 Publication

Cell membrane
Secreted
Released from the cell membrane by GPI cleavage.

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing TDGF1 as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form.