TAF10

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.

TAF10

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).
TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).
TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (PubMed:18206972, PubMed:11564863, PubMed:9885574, PubMed:10373431, PubMed:12601814).
May regulate cyclin E expression (By similarity).

Biological Process allantois developmentIEA:Ensembl
Biological Process apoptotic processIEA:Ensembl
Biological Process DNA-templated transcription initiationIDA:UniProtKB2 Publications
Biological Process embryonic placenta developmentIEA:Ensembl
Biological Process G1/S transition of mitotic cell cycleIEA:Ensembl
Biological Process hepatocyte differentiationIEA:Ensembl
Biological Process histone acetylationIBA:GO_Central1 Publication
Biological Process histone deubiquitinationIDA:UniProtKB1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB2 Publications
Biological Process lateral mesodermal cell differentiationIEA:Ensembl
Biological Process limb developmentIEA:Ensembl
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process multicellular organism growthIEA:Ensembl
Biological Process positive regulation of DNA-templated transcriptionIC:ComplexPortal1 Publication
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process regulation of DNA bindingIEA:Ensembl
Biological Process regulation of DNA repairIC:ComplexPortal2 Publications
Biological Process regulation of DNA-templated transcriptionIC:ComplexPortal1 Publication
Biological Process regulation of RNA splicingIC:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process RNA polymerase II preinitiation complex assemblyIPI:ComplexPortal1 Publication
Biological Process SAGA complex assemblyIEA:Ensembl
Biological Process somitogenesisIEA:Ensembl
Biological Process transcription by RNA polymerase IIIC:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase II promoterIDA:UniProtKB1 Publication

Nucleus

Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II.
Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.