Syt1
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM
Function
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity).
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity).
It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process brain developmentIEA:Ensembl
Biological Process calcium ion-regulated exocytosis of neurotransmitterIBA:GO_Central1 Publication
Biological Process calcium-dependent activation of synaptic vesicle fusionIEA:Ensembl
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionISS:ParkinsonsUK-UCL
Biological Process chemical synaptic transmissionTAS:ProtInc1 Publication
Biological Process detection of calcium ionTAS:UniProtKB1 Publication
Biological Process fast, calcium ion-dependent exocytosis of neurotransmitterISS:ParkinsonsUK-UCL
Biological Process neurotransmitter secretionTAS:UniProtKB1 Publication
Biological Process positive regulation of calcium ion-dependent exocytosis of neurotransmitterISS:UniProtKB
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process positive regulation of dopamine secretionIEA:Ensembl
Biological Process positive regulation of synaptic transmissionISS:ParkinsonsUK-UCL
Biological Process protein heterooligomerizationIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of exocytosisTAS:UniProtKB1 Publication
Biological Process regulation of regulated secretory pathwayISS:ParkinsonsUK-UCL
Biological Process regulation of synaptic transmission, glutamatergicISS:ParkinsonsUK-UCL
Biological Process spontaneous neurotransmitter secretionIEA:Ensembl
Biological Process synaptic vesicle endocytosisIBA:GO_Central1 Publication
Biological Process synchronous neurotransmitter secretionIEA:Ensembl
Biological Process vesicle dockingIEA:Ensembl
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane
Cytoplasm
Involvement in disease
Baker-Gordon syndrome (BAGOS):
An autosomal dominant neurodevelopmental disorder characterized by infantile hypotonia, congenital ophthalmic abnormalities, involuntary and hyperkinetic movements, stereotypic behavior, poor or absent speech, EEG abnormalities, and global developmental delay varying in severity from moderate to profound. Behavioral characteristics include sleep disturbance and episodic agitation.
Topology
Vesicular: 1-57
Helical: 58-80
Cytoplasmic: 81-422
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Datasheet