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STN1

OBFC1 (oligonucleotide/oligosaccharide-binding fold containing 1) is one of subunit of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase, the enzyme that initiates DNA replication. OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1.
Full Name
STN1, CST complex subunit
Function
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130).
However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22964711, PubMed:22763445).
The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).
Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres (PubMed:22863775, PubMed:22964711).
Promotes general replication start following replication-fork stalling implicating new origin firing (PubMed:22863775).
May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (PubMed:23142664).
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
Biological Process
Biological Process negative regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of DNA replicationISS:UniProtKB
Biological Process telomere cappingManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process telomere maintenanceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process telomere maintenance via telomere lengtheningManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Chromosome, telomere
Involvement in disease
Cerebroretinal microangiopathy with calcifications and cysts 2 (CRMCC2):
An autosomal recessive, multisystemic disorder characterized by intrauterine growth retardation and, later in life, premature aging symptoms, including poor growth, graying hair, liver fibrosis, portal hypertension, esophageal varices, osteopenia, pancytopenia, hypocellular bone marrow, and vascular telangiectasia resulting in gastrointestinal bleeding. Brain calcifications and white matter changes are responsible for signs including spasticity, ataxia, or dystonia observed in some patients.

Anti-STN1 antibodies

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Target: STN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G12-1B7
Application*: WB, E
Target: STN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXO-0053
Application*: SE, E, WB
Target: STN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXO-0450
Application*: E, WB
Target: STN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C5
Application*: F, IF, WB
Target: STN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0555
Application*: IP, WB
Target: STN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0018
Application*: E, WB
Target: STN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: 1B4
Application*: IP, WB, M
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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