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STAT4

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. [provided by RefSeq]
Full Name
STAT4
Function
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription by RNA polymerase II2 PublicationsIC:ComplexPortal
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.
Involvement in disease
Systemic lupus erythematosus 11 (SLEB11):
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
PTM
Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).

Anti-STAT4 antibodies

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Target: STAT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C46B10
Application*: WB, IP, CI, CI-seq
Target: STAT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Pig
Clone: D2E4
Application*: FC
Target: STAT4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-6189
Application*: E, IP, WB
Target: STAT4
Host: Hamster
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: ST4.01 (NB.34)
Application*: IP, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: JH46.1.2A2
Application*: IP, WB
Target: STAT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-6158
Application*: CI, WB
Target: STAT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-3412
Application*: WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXS-3109
Application*: E, IP, WB
Target: STAT4
Host: Mouse
Specificity: Human
Clone: CBXS-2964
Application*: E, IF, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2326
Application*: IP, WB
Target: STAT4
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2100
Application*: WB, IP, IF, E
Target: STAT4
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2014
Application*: WB, IP, IF, E
Target: STAT4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXS-1842
Application*: WB
Target: STAT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1189
Application*: WB, IP, P, IC, F
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C2-1C12
Application*: WB, IP, E, IH, IF
Target: STAT4
Host: Mouse
Specificity: Human
Clone: CBXS-5549
Application*: E, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5107
Application*: P, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5074
Application*: F, P, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4779
Application*: F, IF, P, WB
Target: STAT4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-4662
Application*: E, F, IC, IF, P, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4626
Application*: F, IF, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4583
Application*: WB, F, IH, IF, P
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4343
Application*: IH, P, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4277
Application*: WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4213
Application*: IF, P, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4195
Application*: F, IF, WB
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3848
Application*: F, P, WB
Target: STAT4
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBXS-5998
Application*: WB, CI
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9H7
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9H5
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3G3
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3G10
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3E4
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2C6
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 19E9
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16D7
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14C6
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 12H5
Application*: E, M
Target: STAT4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A2
Application*: IP, M
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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