SH3BGRL

SH3 domain binding glutamic acid-rich protein like

Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs (PubMed:34331014).
May function as a ubiquitin ligase-substrate adapter (PubMed:34331014, PubMed:34870550).
Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs (PubMed:34331014, PubMed:34870550).

Biological Process positive regulation of cytoplasmic translational initiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm, cytosol
Cell membrane

Promotes breast cancer progression by enhancing the interaction between E3 ligase STUB1 and PFN1, thereby promoting proteasomal degradation of PFN1 and subsequent activation of downstream signaling pathways including PI3K/AKT, NF-kB and WNT (PubMed:34331014). Promotes autophagy presumably by stabilizing the ubuiquitin-like protein ATG12 (PubMed:34870550). Enhances mRNA translation of E3 ligase STUB1 and the autophagy-related protein PIK3C3 (PubMed:34331014, PubMed:34870550). Promotes activation and phosphorylation of ERBB2 at 'Tyr-877' and 'Tyr-1196', and prolongs localization of ERBB2 to the cell membrane (PubMed:32381043). Breast cancer patients with SH3BGRL overexpression usually experience frequent relapse and poor prognosis (PubMed:32381043, PubMed:34870550).