Robo1

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

roundabout, axon guidance receptor, homolog 1 (Drosophila)

Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577).
Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577).
In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity).
Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257).
May be required for lung development (By similarity).

Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process aorta developmentISS:BHF-UCL
Biological Process aortic valve morphogenesisISS:BHF-UCL
Biological Process axon midline choice point recognitionISS:UniProtKB
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process chemorepulsion involved in postnatal olfactory bulb interneuron migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endocardial cushion formationISS:BHF-UCL
Biological Process homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of gene expressionISS:BHF-UCL
Biological Process negative regulation of mammary gland epithelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of negative chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process outflow tract septum morphogenesisISS:BHF-UCL
Biological Process positive regulation of axonogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of gene expressionISS:BHF-UCL
Biological Process positive regulation of MAP kinase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of Notch signaling pathway involved in heart inductionISS:BHF-UCL
Biological Process positive regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of vascular endothelial growth factor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process pulmonary valve morphogenesisISS:BHF-UCL
Biological Process Roundabout signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ventricular septum morphogenesisISS:BHF-UCL

Cell membrane
Cell projection, axon
Endoplasmic reticulum-Golgi intermediate compartment membrane
Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity).
PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity).

Extracellular: 26-897
Helical: 898-918
Cytoplasmic: 919-1651

Ubiquitinated. May be deubiquitinated by USP33.