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RELT

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Full Name
RELT, TNF Receptor
Function
May play a role in apoptosis (PubMed:28688764, PubMed:19969290).
Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727).
Involved in dental enamel formation (PubMed:30506946).
Biological Process
Biological Process amelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Cytoplasm, perinuclear region
Involvement in disease
Amelogenesis imperfecta 3C (AI3C):
An autosomal recessive form of amelogenesis imperfecta, a defect of enamel formation. AI3C is characterized by generalized enamel hypocalcification affecting primary and secondary dentition. The surface of the enamel is rough and often stained. After eruption, the occlusal enamel on the molars disappears due to attrition, leaving a ring of intact enamel remaining on the sides.
Topology
Extracellular: 26-162
Helical: 163-183
Cytoplasmic: 184-430
PTM
Phosphorylated in vitro by OXSR1 (PubMed:16389068).
Phosphorylated by STK39 (PubMed:16530727).

Anti-RELT antibodies

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Mouse Anti-RELT Recombinant Antibody (3F8) (CBMAB-A9303-LY)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: WB, E

Mouse Anti-RELT Recombinant Antibody (CBYJT-1628) (CBMAB-T0674-YJ)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-1628
Application*: F

Mouse Anti-RELT Recombinant Antibody (CBYJT-1627) (CBMAB-T0673-YJ)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-1627
Application*: E, WB

Rabbit Anti-RELT Recombinant Antibody (CBYJT-1626) (CBMAB-T0672-YJ)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1626
Application*: E

Mouse Anti-RELT Recombinant Antibody (CBYJT-1625) (CBMAB-T0671-YJ)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1625
Application*: IF, IC

RELT Matched Antibody Pair (985) (APMAB-985LY)

Datasheet Datasheet SDS SDS
Target: RELT
Specificity: Human

Mouse Anti-RELT Recombinant Antibody (CBCNR-396) (CBMAB-R2134-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNR-396
Application*: E, WB

Mouse Anti-RELT Recombinant Antibody (8G28) (CBMAB-R2133-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 8G28
Application*: F

Mouse Anti-RELT Recombinant Antibody (3F8) (CBMAB-R2132-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: E, WB

Mouse Anti-RELT Recombinant Antibody (14L820) (CBMAB-R2131-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L820
Application*: F

Rabbit Anti-RELT Recombinant Antibody (135) (CBMAB-R2130-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 135
Application*: E

Rabbit Anti-RELT Recombinant Antibody (111) (CBMAB-R2129-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 111
Application*: E

Mouse Anti-RELT Recombinant Antibody (01) (CBMAB-R2128-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 01
Application*: IF, IF

Mouse Anti-RELT Recombinant Antibody (238104) (CBMAB-R0209-CN)

Datasheet Datasheet SDS SDS
Target: RELT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 238104
Application*: F, MC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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