RAPGEF4

RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with RAPGEF4 include Lesch-Nyhan Syndrome and Acrodysostosis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras GTPase binding. An important paralog of this gene is RAPGEF3.

Rap Guanine Nucleotide Exchange Factor 4

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).

Biological Process adaptive immune responseTAS:Reactome
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process insulin secretionIEA:Ensembl
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisIEA:Ensembl
Biological Process regulation of synaptic vesicle cycleIEA:Ensembl

Cytoplasm
Membrane