RAB3A

RAB3A (RAB3A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB3A include Isolated Growth Hormone Deficiency, Type Ii. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is RAB3C.

RAB3A, member RAS oncogene family

Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity).
Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity).
Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity).
Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity).
Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790).
Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141).
Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity).
Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).

Biological Process acrosomal vesicle exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process calcium-ion regulated exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process constitutive secretory pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process evoked neurotransmitter secretionIEA:Ensembl
Biological Process exocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lung developmentIEA:Ensembl
Biological Process lysosome localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process maintenance of presynaptic active zone structureManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion organizationIEA:Ensembl
Biological Process neuromuscular synaptic transmissionIEA:Ensembl
Biological Process plasma membrane repairManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of exocytosisManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of regulated secretory pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process post-embryonic developmentIEA:Ensembl
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulated exocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of dopamine secretionIEA:Ensembl
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of plasma membrane repairManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of short-term neuronal synaptic plasticityISS:ParkinsonsUK-UCL
Biological Process regulation of synaptic vesicle exocytosisIEA:Ensembl
Biological Process regulation of synaptic vesicle fusion to presynaptic active zone membraneISS:ParkinsonsUK-UCL
Biological Process regulation of synaptic vesicle primingIEA:Ensembl
Biological Process respiratory system processIEA:Ensembl
Biological Process response to electrical stimulusIEA:Ensembl
Biological Process sensory perception of touchIEA:Ensembl
Biological Process synaptic vesicle clusteringIEA:Ensembl
Biological Process synaptic vesicle exocytosisISS:ParkinsonsUK-UCL
Biological Process synaptic vesicle maturationIEA:Ensembl
Biological Process synaptic vesicle recyclingISS:ParkinsonsUK-UCL
Biological Process synaptic vesicle transportIEA:Ensembl
Biological Process vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm, cytosol
Lysosome
Cytoplasmic vesicle, secretory vesicle
Cell projection, axon
Cell membrane
Presynapse
Postsynapse
Cycles between a vesicle-associated GTP-bound form and a cytosolic GDP-bound form.

Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.