PYDC1

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Pyrin domain containing 1

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

Biological Process innate immune responseManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of protein kinase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process proteolysisIEA:InterPro
Biological Process tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:HGNC-UCL

Cytoplasm
Recruited to specks formed by PYCARD within the cytoplasm.

Phosphorylated.