POFUT2

POFUT2 (Protein O-Fucosyltransferase 2) is a protein coding gene. Diseases associated with POFUT2 include Peters-Plus Syndrome. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology annotations related to this gene include fucosyltransferase activity and peptide-O-fucosyltransferase activity.

Protein O-Fucosyltransferase 2

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:22588082).
O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable) (PubMed:17395588).
Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (PubMed:17395589, PubMed:17395588).
The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity).

Fucose metabolic processIEA:UniProtKB-KW
Mesoderm formationIEA:Ensembl
Positive regulation of protein foldingManual Assertion Based On ExperimentIMP:CACAO
Protein O-linked fucosylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epithelial to mesenchymal transitionIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Regulation of secretionManual Assertion Based On ExperimentIDA:UniProtKB

Endoplasmic reticulum
Golgi apparatus
Mainly located in the endoplasmic reticulum.