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PIK3R2

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene.
Full Name
PIK3R2
Function
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).
Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
Biological Process
B cell differentiation1 PublicationIC:ComplexPortal
Cellular glucose homeostasisISS:UniProtKB
Cellular response to insulin stimulusISS:UniProtKB
Immune response1 PublicationIC:ComplexPortal
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein import into nucleusISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Regulation of autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Response to endoplasmic reticulum stressISS:UniProtKB
T cell differentiation1 PublicationIC:ComplexPortal
Cellular Location
cytosol
nucleus
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
Involvement in disease
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1):
A syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
PTM
Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231).
Dephosphorylated by PTPRJ (PubMed:18348712).
Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).
Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.

Anti-PIK3R2 antibodies

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Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: 3H2842
Application*: IH, IP, WB
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 20D7
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 20G7
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B2
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3D4
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 8D9-D5-F8
Application*: WB
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: T15
Application*: WB, IP, C
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBYC-P385
Application*: IH, IP, WB
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 12D11
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16E7
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 18C7
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 19C10
Application*: E, M
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5B2
Application*: E, M
Target: PIK3R2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBAb187
Application*: WB, IH, IF, IP
Target: PIK3R2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb188
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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