PGAP1

PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM

post-GPI attachment to proteins 1

Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).

Anterior/posterior axis specificationIEA:Ensembl
Attachment of GPI anchor to proteinTAS:Reactome
Embryonic pattern specificationIEA:Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Forebrain regionalizationIEA:Ensembl
GPI anchor metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of ER to Golgi vesicle-mediated transportISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Sensory perception of soundIEA:Ensembl

Endoplasmic reticulum membrane

Mental retardation, autosomal recessive 42 (MRT42):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Cytoplasmic: 1-11
Helical: 12-32
Lumenal: 33-641
Helical: 642-662
Cytoplasmic: 663-668
Helical: 669-689
Lumenal: 690-733
Helical: 734-754
Cytoplasmic: 755-817
Helical: 818-838
Lumenal: 839-853
Helical: 854-874
Cytoplasmic: 875-893
Helical: 894-914
Lumenal: 915-922