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PAX5

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Full Name
Paired Box 5
Function
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361).
Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361).
In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238).
Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238).
(Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781).
Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172).
Biological Process
Adult behaviorIEA:Ensembl
AgingIEA:Ensembl
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cerebral cortex developmentIEA:Ensembl
Embryonic cranial skeleton morphogenesisIEA:Ensembl
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Lateral ventricle developmentIEA:Ensembl
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of histone H3-K9 methylationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Skeletal muscle cell differentiationIEA:Ensembl
SpermatogenesisIEA:UniProtKB-KW
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Leukemia, acute lymphoblastic, 3 (ALL3):
A subtype of acute leukemia, a cancer of the white blood cells. Acute lymphoblastic anemia is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes.
PTM
O-glycosylated.
Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation.

Anti-PAX5 antibodies

+ Filters
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Target: PAX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B1
Application*: IP, M
Target: PAX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0244
Application*: F, IC, WB
Target: PAX5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: mAbcam52588
Application*: WB, F
Target: PAX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: BA0245
Application*: F, IC, P, WB
Target: PAX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1EW
Application*: P
Target: PAX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR-0038
Application*: ELISA
Target: PAX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 96
Application*: ELISA, IHC, WB
Target: PAX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: RM331
Application*: IHC, WB
Target: PAX5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 6I4
Application*: IF, IHC-P, ICC, WB
Target: PAX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IHC005
Application*: P, E, IH
Target: PAX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D7H5X
Application*: WB, P, IFF
Target: PAX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Frog
Clone: D19F8
Application*: IF
Target: PAX5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A-11
Application*: WB, IP, IF, P, E
Target: PAX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8F9
Application*: E, P, RNAi, WB
Target: PAX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D3
Application*: E, WB, IH
Target: PAX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A7
Application*: P, WB
Target: PAX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 24/Pax-5
Application*: WB, IF, IH
Target: PAX5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 1H9
Application*: F
Target: PAX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1207C
Application*: IS
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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