NOS1

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]

Nitric Oxide Synthase 1

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

Arginine catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cell redox homeostasisTAS:Reactome
Cellular response to growth factor stimulusISS:BHF-UCL
Multicellular organismal response to stressManual Assertion Based On ExperimentIMP:BHF-UCL
Muscle contractionManual Assertion Based On ExperimentIBA:GO_Central
Myoblast fusionManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of calcium ion transportISS:BHF-UCL
Negative regulation of calcium ion transport into cytosolManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of hydrolase activityISS:BHF-UCL
Negative regulation of potassium ion transportISS:BHF-UCL
Negative regulation of serotonin uptakeISS:BHF-UCL
Neurotransmitter biosynthetic processManual Assertion Based On ExperimentTAS:BHF-UCL
Nitric oxide biosynthetic processBy SimilarityISS:BHF-UCL
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-cysteine S-nitrosylationISS:BHF-UCL
Positive regulation of guanylate cyclase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of histone acetylationISS:BHF-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of sodium ion transmembrane transportISS:BHF-UCL
Positive regulation of the force of heart contractionISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of transcription, DNA-templatedISS:BHF-UCL
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channelManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of cardiac muscle contractionManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activityManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of sodium ion transportISS:BHF-UCL
Response to heatManual Assertion Based On ExperimentIDA:BHF-UCL
Response to hormoneManual Assertion Based On ExperimentIBA:GO_Central
Response to hypoxiaManual Assertion Based On ExperimentIEP:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Retrograde trans-synaptic signaling by nitric oxideManual Assertion Based On ExperimentIBA:GO_Central
Striated muscle contractionISS:BHF-UCL
VasodilationManual Assertion Based On ExperimentIDA:BHF-UCL
Xenobiotic catabolic processISS:BHF-UCL

Cell membrane, sarcolemma
Cell projection, dendritic spine
In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).

Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).