NMBR

This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Neuromedin B Receptor

Receptor for neuromedin-B (PubMed:1655761).
Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity).
These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity).
Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity).
Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264).
Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).

G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc

Cell membrane

Extracellular: 1-41
Helical: 42-65
Cytoplasmic: 66-79
Helical: 80-99
Extracellular: 100-117
Helical: 118-139
Cytoplasmic: 140-156
Helical: 157-177
Extracellular: 178-211
Helical: 212-235
Cytoplasmic: 236-266
Helical: 267-287
Extracellular: 288-299
Helical: 300-327
Cytoplasmic: 328-390