NLGN1

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

Neuroligin 1

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity).
The protein is involved in nervous system development.

AMPA glutamate receptor clusteringISS:BHF-UCL
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesISS:UniProtKB
Cell-cell adhesion involved in synapse maturation1 PublicationIC:ComplexPortal
Cellular response to calcium ionISS:ARUK-UCL
Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Cytoskeletal matrix organization at active zoneISS:BHF-UCL
Establishment of protein localizationISS:BHF-UCL
Excitatory synapse assemblyBy SimilarityISS:ARUK-UCL
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesISS:BHF-UCL
Maintenance of synapse structure1 PublicationIC:ComplexPortal
Modulation of chemical synaptic transmissionISS:ARUK-UCL
Negative regulation of dendritic spine morphogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Nervous system developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neurexin clustering involved in presynaptic membrane assemblyISS:BHF-UCL
Neuron cell-cell adhesionISS:BHF-UCL
Neuron projection arborizationISS:ARUK-UCL
Neuron projection developmentManual Assertion Based On ExperimentIDA:CACAO
Neuron projection morphogenesis1 PublicationIC:ComplexPortal
Neuronal signal transductionManual Assertion Based On ExperimentTAS:BHF-UCL
NMDA glutamate receptor clusteringISS:BHF-UCL
Positive regulation of circadian sleep/wake cycle, wakefulnessISS:UniProtKB
Positive regulation of dendritic spine developmentManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of excitatory postsynaptic potentialManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of filopodium assemblyISS:BHF-UCL
Positive regulation of intracellular signal transductionISS:BHF-UCL
Positive regulation of neuromuscular synaptic transmission1 PublicationIC:ComplexPortal
Positive regulation of neuron projection development1 PublicationIC:ComplexPortal
Positive regulation of ruffle assemblyISS:BHF-UCL
Positive regulation of synapse assemblyManual Assertion Based On ExperimentIDA:MGI
Positive regulation of synaptic transmission, GABAergicISS:BHF-UCL
Positive regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Positive regulation of synaptic vesicle clusteringIEA:Ensembl
Positive regulation of synaptic vesicle endocytosisISS:BHF-UCL
Positive regulation of synaptic vesicle exocytosisISS:BHF-UCL
Postsynaptic density protein 95 clusteringISS:BHF-UCL
Postsynaptic membrane assemblyISS:BHF-UCL
Postsynaptic specialization assemblyIEA:Ensembl
Presynapse assemblyManual Assertion Based On ExperimentTAS:ARUK-UCL
Presynaptic membrane assemblyISS:BHF-UCL
Protein localization to synapseISS:BHF-UCL
Protein targetingISS:UniProtKB
Receptor localization to synapseISS:BHF-UCL
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of neuron differentiationISS:UniProtKB
Regulation of NMDA receptor activityManual Assertion Based On ExperimentIGI:BHF-UCL
Regulation of respiratory gaseous exchange by nervous system processIEA:Ensembl
Rhythmic processIEA:UniProtKB-KW
Synapse assemblyISS:UniProtKB
Synapse maturation1 PublicationIC:ComplexPortal
Synaptic membrane adhesionIEA:Ensembl
Synaptic vesicle clusteringISS:BHF-UCL
Synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Synaptic vesicle targetingISS:UniProtKB
Terminal button organizationISS:BHF-UCL

Cell membrane
Cell junction, synapse, postsynaptic density
Cell junction, synapse, synaptic cleft
Cell junction, synapse, synaptic cell membrane
Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1.

Autism 20 (AUTS20):
A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. The transmission pattern of AUTS20 is consistent with autosomal dominant inheritance.

Extracellular: 46-717
Helical: 718-738
Cytoplasmic: 739-863