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NCOA3

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Full Name

Nuclear Receptor Coactivator 3

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Biological Process

Cell dedifferentiation Source: UniProtKB
Cellular response to estradiol stimulus Source: BHF-UCL
Cellular response to hormone stimulus Source: GO_Central
Positive regulation of keratinocyte differentiation Source: UniProtKB
Positive regulation of stem cell population maintenance Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Receptor transactivation Source: UniProtKB
Regulation of stem cell division Source: UniProtKB

Cellular Location

Nucleus
Cytoplasm
Note: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

PTM

Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
Methylated
Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.

Anti-NCOA3 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-NCOA3 Recombinant Antibody (11B1) (CBMAB-CP2577-LY)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11B1

Application*: WB, IF (IC), F

Rabbit Anti-NCOA3 Recombinant Antibody (D1F11) (CBMAB-CP2576-LY)

SDS

Target: NCOA3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey

Clone: D1F11

Application*: WB, IP, IF (IC)

Rabbit Anti-NCOA3 Recombinant Antibody (5E11) (CBMAB-CP2575-LY)

SDS

Target: NCOA3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: 5E11

Application*: WB, IP, CI, CI-seq

Mouse Anti-NCOA3 Recombinant Antibody (CBXS-3449) (CBMAB-S6180-CQ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3449

Application*: WB

Rabbit Anti-NCOA3 Recombinant Antibody (CBXS-1512) (CBMAB-S4365-CQ)

SDS

Target: NCOA3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1512

Application*: WB, P, F, IF

Mouse Anti-NCOA3 Recombinant Antibody (CBXS-0049) (CBMAB-S3050-CQ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0049

Application*: P, WB

Mouse Anti-NCOA3 Recombinant Antibody (AX15.3) (CBMAB-S2958-CQ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: AX15.3

Application*: E, IH, P, IP, WB, CI

Mouse Anti-NCOA3 Recombinant Antibody (AX 15) (CBMAB-S2957-CQ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: AX 15

Application*: IP, WB

Rabbit Anti-NCOA3 Recombinant Antibody (CBXS-5347) (CBMAB-S2560-CQ)

SDS

Target: NCOA3

Host: Rabbit

Specificity: Human, Mouse, Monkey

Clone: CBXS-5347

Application*: WB, IP, IF

Mouse Anti-NCOA3 Recombinant Antibody (CBXS-3650) (CBMAB-S0929-CQ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-3650

Application*: F, IF, WB

Rabbit Anti-NCOA3 Recombinant Antibody (CBXS-5751) (CBMAB-S0612-CQ)

SDS

Target: NCOA3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: CBXS-5751

Application*: WB, IP, CI

Mouse Anti-NCOA3 Recombinant Antibody (6D102) (CBMAB-A4610-YC)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D102

Application*: IP, WB

Mouse Anti-NCOA3 Recombinant Antibody (4i291) (CBMAB-A4607-YC)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4i291

Application*: WB

Mouse Anti-NCOA3 Recombinant Antibody (34/AIB-1) (CBMAB-A4606-YC)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 34/AIB-1

Application*: WB, IF

Mouse Anti-NCOA3 Recombinant Antibody (13B18) (CBMAB-A4605-YC)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13B18

Application*: E, WB

Mouse Anti-NCOA3 Recombinant Antibody (CBWJN-0783) (CBMAB-N1454-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-0783

Application*: IP, WB

Mouse Anti-NCOA3 Recombinant Antibody (CBWJN-0782) (CBMAB-N1453-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-0782

Application*: IP

Mouse Anti-NCOA3 Recombinant Antibody (CBWJN-0781) (CBMAB-N1452-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0781

Application*: IP

Mouse Anti-NCOA3 Recombinant Antibody (F-2) (CBMAB-N1451-WJ)

SDS

Target: NCOA3

Host: Mouse

Specificity: Human, Mouse, Rat

Clone: F-2

Application*: WB, IP, IF, E

Rabbit Anti-NCOA3 Recombinant Antibody (CBWJN-1220) (CBMAB-N1450-WJ)

SDS

Target: NCOA3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-1220

Application*: WB, P, IC, F

Mouse Anti-NCOA3 Recombinant Antibody (E-11) (CBMAB-N1449-WJ)

SDS

Target: NCOA3

Host: Mouse

Specificity: Human

Clone: E-11

Application*: WB, IP, IF, E

Mouse Anti-NCOA3 Recombinant Antibody (B-3) (CBMAB-N1448-WJ)

SDS

Target: NCOA3

Host: Mouse

Specificity: Human

Clone: B-3

Application*: WB, IP, IF, E

Mouse Anti-NCOA3 Recombinant Antibody (5H3) (CBMAB-N1447-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5H3

Application*: E, WB

Mouse Anti-NCOA3 Recombinant Antibody (4H9) (CBMAB-N1445-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4H9

Application*: WB

Mouse Anti-NCOA3 Recombinant Antibody (2C11B12) (CBMAB-N1444-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C11B12

Application*: WB

Mouse Anti-NCOA3 Recombinant Antibody (2C1) (CBMAB-N1443-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2C1

Application*: WB, IP

Mouse Anti-NCOA3 Recombinant Antibody (CBWJN-0128) (CBMAB-N1442-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0128

Application*: E, WB

Mouse Anti-NCOA3 Recombinant Antibody (AC3) (CBMAB-N0184-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: AC3

Application*: WB, IH, IF, P

Mouse Anti-NCOA3 Recombinant Antibody (CBWJN-0311) (CBMAB-N0183-WJ)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0311

Application*: DB, WB

Mouse Anti-NCOA3 Antibody (1C10) (CBMAB-0710-YC)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 1C10

Application*: IP, M

Mouse Anti-NCOA3 Antibody (1B9) (CBMAB-0709-YC)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1B9

Application*: IP, M

Mouse Anti-NCOA3 Antibody (1A11) (CBMAB-0708-YC)

SDS

Target: NCOA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A11

Application*: IP, M

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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