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MUC2

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]

Full Name

Mucin 2, Oligomeric Mucus/Gel-Forming

Function

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Biological Process

Maintenance of gastrointestinal epithelium Source: UniProtKB

Cellular Location

Secreted
Note: In the intestine, secreted into the inner and outer mucus layers.

PTM

O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

Anti-MUC2 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-MUC2 Recombinant Antibody (A1238) (CBMAB-AP4893LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1238

Application*: FC, IF, IHC

Mouse Anti-MUC2 Recombinant Antibody (A1237) (CBMAB-AP4923LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1237

Application*: FC, IF, IHC

Mouse Anti-MUC2 Recombinant Antibody (A1236) (CBMAB-AP12298LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: A1236

Application*: IHC

Mouse Anti-MUC2 Recombinant Antibody (A1235) (CBMAB-AP4894LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1235

Application*: FC, IF, IHC

Mouse Anti-MUC2 Recombinant Antibody (A1234) (CBMAB-AP4924LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1234

Application*: FC, IF, IHC

Mouse Anti-MUC2 Recombinant Antibody (A1233) (CBMAB-AP4929LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A1233

Application*: ICC, IHC, IP, WB

Mouse Anti-MUC2 Recombinant Antibody (A1232) (CBMAB-AP4922LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: A1232

Application*: ELISA, IHC

Mouse Anti-MUC2 Recombinant Antibody (IHC624) (CBMAB-MA174-YC)

SDS

Target: MUC2

Host: Mouse

Specificity: Human

Clone: IHC624

Application*: IH

Mouse Anti-MUC2 Recombinant Antibody (4A8) (CBMAB-A5687-LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4A8

Application*: IF, E

Mouse Anti-MUC2 Recombinant Antibody (4A4) (CBMAB-A5686-LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4A4

Application*: E, E

Mouse Anti-MUC2 Recombinant Antibody (1H2) (CBMAB-A5681-LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1H2

Application*: E, E

Mouse Anti-MUC2 Recombinant Antibody (1D10) (CBMAB-A5680-LY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D10

Application*: E, E

Recombinant Mouse Anti-MUC2 Recombinant Antibody (996/1) (CBMAB-XB0850-YC)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 996/1

Application*: F, IH, WB

Recombinant Mouse Anti-MUC2 Recombinant Antibody (994/152) (CBMAB-XB0849-YC)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 994/152

Application*: E, IH

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-2804) (CBMAB-M2997-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2804

Application*: F

Mouse Anti-MUC2 (AA 4993-5078) Recombinant Antibody (CBFYM-2803) (CBMAB-M2996-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2803

Application*: E, IF

Mouse Anti-MUC2 (AA 5081-5179) Recombinant Antibody (CBFYM-2802) (CBMAB-M2995-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2802

Application*: E

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-2801) (CBMAB-M2994-FY)

SDS

Target: MUC2

Host: Mouse

Specificity: Human

Clone: CBFYM-2801

Application*: WB, IC, P, C, E

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-2800) (CBMAB-M2993-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-2800

Application*: E, F, C, P, WB

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0746) (CBMAB-M0888-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-0746

Application*: IH, WB

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0745) (CBMAB-M0887-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0745

Application*: IH, WB

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0424) (CBMAB-M0538-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0424

Application*: C, F, IF, IP, P, WB

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0365) (CBMAB-M0446-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0365

Application*: F, IF, P

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0254) (CBMAB-M0317-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0254

Application*: E, F, IF, IH, IP, WB

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0229) (CBMAB-M0274-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYM-0229

Application*: WB, F, P, C

Mouse Anti-MUC2 Recombinant Antibody (CBFYM-0228) (CBMAB-M0273-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0228

Application*: E

Mouse Anti-MUC2 Monoclonal Antibody (MRQ-18) (CBMAB-R0059-FY)

SDS

Target: MUC2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: MRQ-18

Application*: ELISA

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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