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MLANA

MLANA (Melan-A) is a Protein Coding gene. Diseases associated with MLANA include Melanoma and Microphthalmia. Among its related pathways are NF-kappaB Signaling.
Full Name
Melan-A
Function
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Biological Process
Golgi apparatus
trans-Golgi network membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Melanosome
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Topology
Helical: 27-47
Cytoplasmic: 48-118
PTM
Acylated.

Anti-MLANA antibodies

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Mouse Anti-MLANA Recombinant Antibody (A1124) (CBMAB-AP4396LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse
Clone: A1124
Application*: FC, IF, IHC, WB

Mouse Anti-MLANA Recombinant Antibody (A1123) (CBMAB-AP4394LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: A1123
Application*: FC, IF, IHC, WB

Mouse Anti-MLANA Recombinant Antibody (A1122) (CBMAB-AP4392LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Horse
Clone: A1122
Application*: FC, IF, IHC, WB

Mouse Anti-MLANA Recombinant Antibody (A1121) (CBMAB-AP4372LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse
Clone: A1121
Application*: FC, IF, IHC, WB

Mouse Anti-MLANA Recombinant Antibody (A1120) (CBMAB-AP4395LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: A1120
Application*: FC, IF, IHC, WB

Mouse Anti-MLANA Recombinant Antibody (A1119) (CBMAB-AP4393LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Horse
Clone: A1119
Application*: FC, IF, IHC, WB

Mouse Anti-MLANA Recombinant Antibody (A1118) (CBMAB-AP4391LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse
Clone: A1118
Application*: FC, IF, IHC, WB

Mouse Anti-MLANA Recombinant Antibody (A1117) (CBMAB-AP11891LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A1117
Application*: ELISA, IHC

Rabbit Anti-MLANA Recombinant Antibody (RM333) (CBMAB-BR354LY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM333
Application*: IHC, WB

Mouse Anti-MLANA Recombinant Antibody (IHC408) (CBMAB-MA162-YC)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Specificity: Human
Clone: IHC408
Application*: P, E, IH

Recombinant Mouse Anti-MLANA Recombinant Antibody (A103) (CBMAB-XB0815-YC)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A103
Application*: IH

Rabbit Anti-MLANA (C-terminus) Recombinant Antibody (CBFYM-2279) (CBMAB-M2464-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2279
Application*: C, P

Mouse Anti-MLANA Recombinant Antibody (CBFYM-2278) (CBMAB-M2463-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2278
Application*: C, P, IP, WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-2277) (CBMAB-M2462-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2277
Application*: F, P, IP, WB

Mouse Anti-MLANA (AA 60-92) Recombinant Antibody (CBFYM-2276) (CBMAB-M2461-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2276
Application*: WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-2275) (CBMAB-M2460-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2275
Application*: IF, P, WB

Mouse Anti-MLANA (AA 48-118) Recombinant Antibody (CBFYM-2274) (CBMAB-M2459-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2274
Application*: WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-2273) (CBMAB-M2458-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2273
Application*: WB, IH, IF

Mouse Anti-MLANA Recombinant Antibody (CBFYM-2272) (CBMAB-M2457-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Horse, Human
Clone: CBFYM-2272
Application*: IH, IP, WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-2270) (CBMAB-M2455-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human
Clone: CBFYM-2270
Application*: IH, IP, WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-0654) (CBMAB-M0790-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-0654
Application*: IH, IP, WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-0653) (CBMAB-M0789-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0653
Application*: IH, IP, WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-0432) (CBMAB-M0547-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYM-0432
Application*: C, F, IF, IP, P, WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-0431) (CBMAB-M0546-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYM-0431
Application*: C, F, IF, IP, P, WB

Mouse Anti-MLANA Recombinant Antibody (CBFYM-0427) (CBMAB-M0541-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Horse, Human
Clone: CBFYM-0427
Application*: F, IF, P

Mouse Anti-MLANA Recombinant Antibody (CBFYM-0364) (CBMAB-M0445-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog
Clone: CBFYM-0364
Application*: F, IF, WB, C

Rabbit Anti-MLANA Recombinant Antibody (CBFYM-0363) (CBMAB-M0444-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYM-0363
Application*: F, IF, P, WB

Mouse Anti-MLANA (AA 48-118) Recombinant Antibody (CBFYM-0113) (CBMAB-M0131-FY)

Datasheet Datasheet SDS SDS
Target: MLANA
Host: Mouse
Specificity: Human
Clone: CBFYM-0113
Application*: WB, E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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