MGST3

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides. [provided by RefSeq]

microsomal glutathione S-transferase 3

Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457).

Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457).

May participate in the lipid metabolism (PubMed:9278457).

Leukotriene biosynthetic process Source: BHF-UCL
Lipid metabolic process Source: BHF-UCL

Endoplasmic reticulum
Endoplasmic reticulum membrane
Microsome membrane
Other locations
Membrane