MFF

This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Mitochondrial Fission Factor

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.

Mitochondrial fission Source: UniProtKB
Mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
Mitochondrial fusion Source: UniProtKB
Mitochondrion morphogenesis Source: MGI
Peroxisome fission Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Positive regulation of protein targeting to membrane Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Protein targeting to mitochondrion Source: UniProtKB
Regulation of mitochondrion organization Source: UniProtKB
Regulation of peroxisome organization Source: UniProtKB
Release of cytochrome c from mitochondria Source: UniProtKB

Peroxisome
Mitochondrion
Mitochondrion outer membrane
Other locations
synaptic vesicle

Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2):
An autosomal recessive disorder characterized by delayed psychomotor development, severe hypotonia with inability to walk, microcephaly, and abnormal signals in the basal ganglia. More variable features include early-onset seizures, optic atrophy, and peripheral neuropathy.

Cytoplasmic: 1-322
Helical: 323-340
Mitochondrial intermembrane: 341-342