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MEN1

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.
Full Name
MEN1
Function
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity).

May be involved in DNA repair.
Biological Process
Brain development Source: Ensembl
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to glucose stimulus Source: Ensembl
Cellular response to peptide hormone stimulus Source: Ensembl
Chromatin organization Source: UniProtKB-KW
Decidualization Source: Ensembl
DNA repair Source: UniProtKB
Histone H3-K4 methylation Source: UniProtKB
MAPK cascade Source: UniProtKB
Mitotic cell cycle Source: Ensembl
Negative regulation of cell cycle Source: UniProtKB
Negative regulation of cell cycle G1/S phase transition Source: Ensembl
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of cell-substrate adhesion Source: Ensembl
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
Negative regulation of DNA-binding transcription factor activity Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: Ensembl
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of osteoblast differentiation Source: MGI
Negative regulation of protein phosphorylation Source: UniProtKB
Negative regulation of telomerase activity Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Osteoblast development Source: MGI
Positive regulation of protein binding Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Regulation of activin receptor signaling pathway Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of type B pancreatic cell proliferation Source: Ensembl
Response to gamma radiation Source: UniProtKB
Response to transforming growth factor beta Source: Ensembl
Response to UV Source: UniProtKB
Type B pancreatic cell differentiation Source: Ensembl
Cellular Location
Nucleus
Note: Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
Involvement in disease
Familial multiple endocrine neoplasia type I (MEN1):
Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
MEN1 inactivating mutations are responsible for hyperfunctioning of the parathyroid glands and subsequent primary hyperparathyroidism. Primary hyperparathyroidism can occur in isolation or in association with multiple endocrine neoplasia.

Anti-MEN1 antibodies

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Target: MEN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2B1
Application*: IP, WB, M
Target: MEN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H6
Application*: IP, WB, M
Target: MEN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D33C1
Application*: WB, IP
Target: MEN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Pig, Horse
Clone: D45B1
Application*: WB, IF (IC)
Target: MEN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Pig, Horse
Clone: CBFYM-2065
Application*: WB, IF
Target: MEN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2064
Application*: WB, IP
Target: MEN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2063
Application*: P, IP, WB
Target: MEN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2062
Application*: E, WB, P, IF, F
Target: MEN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9BA1
Application*: E, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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