MARCO

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

Macrophage Receptor With Collagenous Structure

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508).

Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity).

Binds to the secretoglobin SCGB3A2 (PubMed:12847263).

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
Amyloid-beta clearance Source: ARUK-UCL
Apoptotic cell clearance Source: Ensembl
Cell surface receptor signaling pathway Source: ProtInc
Endocytosis Source: GO_Central
Innate immune response Source: UniProtKB-KW
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: ARUK-UCL
Receptor-mediated endocytosis Source: ARUK-UCL

Plasma membrane
Cell membrane

Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-520

N-glycosylated.