LNPEP

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.

leucyl and cystinyl aminopeptidase

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.

Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTAS:Reactome
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Peptide catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Protein catabolic processIEA:Ensembl
Protein polyubiquitinationTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionIEA:Ensembl

Cell membrane
In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Leucyl-cystinyl aminopeptidase, pregnancy serum form
Secreted
During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.

Cytoplasmic: 1-110
Helical: 111-131
Extracellular: 132-1025

The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
N-glycosylated.