LMAN1

The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport.

Full Name

lectin, mannose-binding, 1

Function

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.

Biological Process

Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
Endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Positive regulation of organelle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentTAS:ProtInc
Protein transportIEA:UniProtKB-KW

Cellular Location

Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Endoplasmic reticulum membrane

Involvement in disease

Factor V and factor VIII combined deficiency 1 (F5F8D1):
A blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.

Topology

Lumenal: 31-477
Helical: 478-498
Cytoplasmic: 499-510

PTM

The N-terminal may be partly blocked.

Anti-LMAN1 antibodies

+ Filters

Rabbit Anti-LMAN1 Recombinant Antibody (E2B6H) (CBMAB-CP1399-LY)

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Target: LMAN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: E2B6H

Application*: WB

Datasheet SDS

Rat Anti-LMAN1 Recombinant Antibody (CBFYM-1219) (CBMAB-M1376-FY)

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Target: LMAN1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYM-1219

Application*: IA, IF, C, WB

Datasheet SDS

Rat Anti-LMAN1 Recombinant Antibody (CBFYM-1218) (CBMAB-M1375-FY)

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Target: LMAN1

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYM-1218

Application*: E, WB, IH, IF

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (CBFYM-0775) (CBMAB-M0918-FY)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYM-0775

Application*: E, IH, WB

Datasheet SDS

Rabbit Anti-LMAN1 Recombinant Antibody (CBYCL-364) (CBMAB-L0265-YC)

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Target: LMAN1

Host: Rabbit

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBYCL-364

Application*: E, WB, IC

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (CBYCL-363) (CBMAB-L0264-YC)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-363

Application*: E, F, IC, C, IP, WB

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (CBYJL-1804) (CBMAB-L1745-YJ)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Pig, Monkey

Clone: CBYJL-1804

Application*: WB, IP, C, F, IC, IF

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (2B10) (CBMAB-L1742-YJ)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 2B10

Application*: IF, WB

Datasheet SDS

Rabbit Anti-LMAN1 Recombinant Antibody (CBYJL-1801) (CBMAB-L1741-YJ)

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Target: LMAN1

Host: Rabbit

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBYJL-1801

Application*: E, WB

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (CBYJL-1799) (CBMAB-L1739-YJ)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1799

Application*: F

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (CBYJL-1798) (CBMAB-L1738-YJ)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1798

Application*: WB

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (CBFYE-1493) (CBMAB-E2126-FY)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1493

Application*: E, F, IC, C, IP, WB

Datasheet SDS

Mouse Anti-LMAN1 Recombinant Antibody (CBFYE-1492) (CBMAB-E2125-FY)

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Target: LMAN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Monkey, Dog

Clone: CBFYE-1492

Application*: F, IF, IH, WB

Datasheet SDS

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion

IEImmunoelectrophoresis
IFImmunofluorescence
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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