ITGA2B
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia.
Full Name
Integrin Subunit Alpha 2b
Alternative Names
Integrin Subunit Alpha 2b
Function
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Biological Process
Cell-matrix adhesionIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentHDA:UniProtKB
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentHDA:UniProtKB
Cellular Location
Membrane
Involvement in disease
Glanzmann thrombasthenia 1 (GT1):
A form of Glanzmann thrombasthenia, a disorder characterized by failure of platelet aggregation, absent or diminished clot retraction, and mucocutaneous bleeding of mild-to-moderate severity. Glanzmann thrombasthenia has been classified into clinical types I and II. In type I, platelets show absence of glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express glycoprotein IIb-IIIa complexes at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. GT1 inheritance is autosomal recessive.
Bleeding disorder, platelet-type, 16 (BDPLT16):
An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities.
A form of Glanzmann thrombasthenia, a disorder characterized by failure of platelet aggregation, absent or diminished clot retraction, and mucocutaneous bleeding of mild-to-moderate severity. Glanzmann thrombasthenia has been classified into clinical types I and II. In type I, platelets show absence of glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express glycoprotein IIb-IIIa complexes at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. GT1 inheritance is autosomal recessive.
Bleeding disorder, platelet-type, 16 (BDPLT16):
An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities.
Topology
Extracellular: 32-993
Helical: 994-1019
Cytoplasmic: 1020-1039
Helical: 994-1019
Cytoplasmic: 1020-1039
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Anti-ITGA2B antibodies
+ Filters
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CompareTarget: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB271
Application*: IF, FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Cattle
Clone: IVA30
Application*: E, F, IP
Target: ITGA2B
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0814
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1159
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: MBC314.5
Application*: WB
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-C0287
Application*: F, IH, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4610
Application*: IH, F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3655
Application*: IH, F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT306
Application*: P, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EC178
Application*: P
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Q90
Application*: IHC: 1:100
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A665
Application*: ELISA, IHC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A664
Application*: FC, IHC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 80
Application*: ELISA, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5D1
Application*: IHC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB477A
Application*: ELISA, IHC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: HIP7
Application*: ELISA, FC, IHC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HIP11
Application*: ELISA, FC, IHC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB274
Application*: IF, FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB273
Application*: IF, FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB272
Application*: IF, FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB270
Application*: IF, FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb350
Application*: IHC-F, IHC-P, WB
Target: ITGA2B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D8V7H
Application*: WB, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H7-B6
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H7-B6
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Y8
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mink, Pig
Clone: MM2-356
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: VIPL3
Application*: F
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MWReg30
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TBP8
Application*: IF/IC, C
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0232
Application*: C, P, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SZ.22
Application*: IH, IF, FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9A118
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 5F36
Application*: FC, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H96
Application*: E
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H94
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 14D37
Application*: FC, IF, IH
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: VM16a
Application*: FC, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PM6/248
Application*: FC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3861
Application*: E, F, IH
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: HIP2
Application*: F, IH
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3860
Application*: E, F, IH
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3859
Application*: F, IC, IP, FN
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3858
Application*: IP, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3856
Application*: IC, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Sheep
Clone: CO.35E4
Application*: E, F, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CLB-48
Application*: F, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3855
Application*: E, C, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-3854
Application*: F, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: HIP8
Application*: F, IH
Target: ITGA2B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2217
Application*: WB, P
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBWJC-2216
Application*: E, F, FN, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2215
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: 2C10/1
Application*: IH, IP, WB
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1613
Application*: F, IH, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-06
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: VIPL2
Application*: WB, F, IH, C
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P256
Application*: WB, IH
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: PAC-1
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14D156
Application*: WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2591
Application*: E, WB
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C2590
Application*: F, IC, IH
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C2589
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2588
Application*: E, F, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2587
Application*: F, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2586
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C2584
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2582
Application*: E, WB
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C2581
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1437
Application*: IP, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D265
Application*: F, IC, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2802
Application*: F, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CBFYC-2801
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CBFYC-2800
Application*: F, IF, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: CBFYC-2798
Application*: F, IH, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2796
Application*: IH, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2794
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2793
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse
Clone: CBFYC-2792
Application*: IH, WB
Target: ITGA2B
Host: Mouse
Specificity: Human
Clone: CBFYC-2791
Application*: F, IF, IH, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: CBFYC-0224
Application*: F
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0139
Application*: F
Target: ITGA2B
Host: Rabbit
Specificity: Human
Clone: CBYY-I1695
Application*: WB, IP
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0818
Application*: F, C
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0542
Application*: F, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Baboon, Mustelid
Clone: CBYY-I0398
Application*: F
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I0366
Application*: E, F, IP, C, FN
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0312
Application*: F, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M148
Application*: F, IH, IF, IP, FN, MC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Dog
Clone: CBYY-I0261
Application*: F, E, IP, MC
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CRC64
Application*: F, FN, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0260
Application*: F, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0020
Application*: F, IH, C, MC, IF, WB, E
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYY-I0019
Application*: E, F, IH
Target: ITGA2B
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 7H180
Application*: E, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 745201
Application*: E, C, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D266
Application*: IP, WB
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F38
Application*: F, IF
Target: ITGA2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5F35
Application*: F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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