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IL5

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Full Name
Interleukin 5
Alternative Names
Interleukin 5
Function
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Biological Process
Cytokine-mediated signaling pathwayIEA:Ensembl
Immune responseIEA:InterPro
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of B cell proliferationIEA:Ensembl
Positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Positive regulation of eosinophil differentiationIEA:Ensembl
Positive regulation of immunoglobulin productionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB
Positive regulation of podosome assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Positive regulation of transcription, DNA-templatedIEA:Ensembl
Cellular Location
Secreted
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Anti-IL5 antibodies

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Mouse Anti-IL5 Recombinant Antibody (CBYY-I1108) (CBMAB-I2276-YY)

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Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: CBYY-I1108
Application*: ED
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0650) (CBMAB-I1463-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I0650
Application*: E
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (AG112) (V2LY-0524-LY168)

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Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: AG112
Application*: MC, E, F, IH, In Vivo, N, WB
In Vivo Assay Functional Assay
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I1134) (CBMAB-I2302-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Guinea pig, Human, Mouse
Clone: CBYY-I1134
Application*: E, F, WB
Datasheet SDS

Mouse Anti-IL5 Recombinant Antibody (CBYY-I1040) (CBMAB-I2208-YY)

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Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1040
Application*: IH, WB
Datasheet SDS

Mouse Anti-IL5 Recombinant Antibody (9906) (CBMAB-I1822-YY)

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Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9906
Application*: WB, IS, IC, MC
Datasheet SDS

Mouse Anti-IL5 Recombinant Antibody (CBYY-I0800) (CBMAB-I1781-YY)

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Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0800
Application*: E, F, IH, WB
Datasheet SDS

Mouse Anti-IL5 Recombinant Antibody (CBYY-I0678) (CBMAB-I1498-YY)

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Target: IL5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cat
Clone: CBYY-I0678
Application*: N, EC
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0669) (CBMAB-I1482-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0669
Application*: E
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0668) (CBMAB-I1481-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBYY-I0668
Application*: E, F, IF, N, WB
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0651) (CBMAB-I1464-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I0651
Application*: E, F, IF, WB
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (5A10) (CBMAB-I1411-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5A10
Application*: E, WB
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0477) (CBMAB-I1119-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I0477
Application*: N, E
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (TRFK5) (CBMAB-I1118-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: TRFK5
Application*: E, ES, IS, IH, N, WB, MC, MC, FN
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (TRFK4) (CBMAB-I1117-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: TRFK4
Application*: E, I, WB, N
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (JES1-5A10) (CBMAB-I0593-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: JES1-5A10
Application*: EC, ED, ES, F
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (JES1-39D10) (CBMAB-I0592-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: JES1-39D10
Application*: E, IF, WB, ED, F, C, IC
Datasheet SDS

Mouse Anti-IL5 Recombinant Antibody (299298) (CBMAB-I0591-YY)

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Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 299298
Application*: IC, IF, N
Datasheet SDS

Mouse Anti-IL5 Recombinant Antibody (CBYY-I0227) (CBMAB-I0590-YY)

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Target: IL5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBYY-I0227
Application*: N
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0023) (CBMAB-I0046-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0023
Application*: E, EC, ED
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0005) (CBMAB-I0004-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Monkey
Clone: CBYY-I0005
Application*: IS
Datasheet SDS

Rat Anti-IL5 Recombinant Antibody (CBYY-I0003) (CBMAB-I0002-YY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I0003
Application*: F, BL, N, MC
Datasheet SDS

Rat Anti- IL5 Recombinant Antibody (TRFK5) (CBMAB-1110-LY)

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Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: TRFK5
Application*: N
Functional Assay
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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