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IL1RN

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]

Full Name

Interleukin 1 Receptor Antagonist

Function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Cellular Location

Isoform 1: Secreted
Isoform 2&3&4: Cytoplasm

Involvement in disease

Microvascular complications of diabetes 4 (MVCD4):
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Interleukin 1 receptor antagonist deficiency (DIRA):
A rare autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.

Anti-IL1RN antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

IL1RN Matched Antibody Pair (631) (APMAB-631LY)

SDS

Target: IL1RN

Specificity: Human

IL1RN Matched Antibody Pair (630) (APMAB-630LY)

SDS

Target: IL1RN

Specificity: Human

IL1RN Matched Antibody Pair (629) (APMAB-629LY)

SDS

Target: IL1RN

Specificity: Human

IL1RN Matched Antibody Pair (628) (APMAB-628LY)

SDS

Target: IL1RN

Specificity: Human

Recombinant Mouse Anti-IL1RN Antibody (CBHb151) (CBMAB-Hb568-LY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb151

Application*: IHC-F, Immuno assays, WB

Mouse Anti-IL1RN Recombinant Antibody (20D8) (CBMAB-CP1153-LY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 20D8

Application*: WB

Mouse Anti-IL1RN Recombinant Antibody (S14) (CBMAB-A4386-LY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: S14

Application*: WB, E

Mouse Anti-IL1RN Recombinant Antibody (CBFYA-0094) (CBMAB-X0137-FY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYA-0094

Application*: C, IA, WB

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I2019) (CBMAB-I3189-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-I2019

Application*: WB, IH

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1981) (CBMAB-I3151-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-I1981

Application*: WB

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1978) (CBMAB-I3148-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I1978

Application*: WB

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1976) (CBMAB-I3146-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1976

Application*: WB

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1958) (CBMAB-I3128-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-I1958

Application*: WB, IH

Rat Anti-IL1RN Recombinant Antibody (CBYY-I1089) (CBMAB-I2257-YY)

SDS

Target: IL1RN

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-I1089

Application*: WB

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1078) (CBMAB-I2246-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-I1078

Application*: E

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I1008) (CBMAB-I2176-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I1008

Application*: WB

Rabbit Anti-IL1RN Recombinant Antibody (CBYY-I0966) (CBMAB-I2134-YY)

SDS

Target: IL1RN

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-I0966

Application*: P

Mouse Anti-IL1RN Recombinant Antibody (AS17) (CBMAB-I1913-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: AS17

Application*: F, IS, E

Rat Anti-IL1RN Recombinant Antibody (CBYY-I0696) (CBMAB-I1530-YY)

SDS

Target: IL1RN

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYY-I0696

Application*: WB

Mouse Anti-IL1RN Recombinant Antibody (5F11H11) (CBMAB-I1444-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5F11H11

Application*: E, WB

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I0279) (CBMAB-I0783-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0279

Application*: E

Mouse Anti-IL1RN Recombinant Antibody (2D11) (CBMAB-I0473-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2D11

Application*: E, WB, C, C, F, R

Mouse Anti-IL1RN Recombinant Antibody (1H5) (CBMAB-I0472-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1H5

Application*: E, IP, WB

Mouse Anti-IL1RN Recombinant Antibody (10309) (CBMAB-I0471-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 10309

Application*: N, E

Rabbit Anti-IL1RN Recombinant Antibody (CBYY-I0167) (CBMAB-I0470-YY)

SDS

Target: IL1RN

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-I0167

Application*: F, IF, IF

Mouse Anti-IL1RN Recombinant Antibody (CBYY-I0164) (CBMAB-I0465-YY)

SDS

Target: IL1RN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-I0164

Application*: IF, F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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