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IL18R1

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq]

Full Name

interleukin 18 receptor 1

Function

Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).

Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).

Biological Process

Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 22-329
Helical: 330-350
Cytoplasmic: 351-541

PTM

N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.

Anti-IL18R1 antibodies

Mouse Anti-IL18R1 Recombinant Antibody (44G6) (CBMAB-C6499-LY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 44G6

Application*: F

Rat Anti-IL18R1 Recombinant Antibody (CBYY-C2558) (CBMAB-C3999-YY)

SDS

Target: IL18R1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-C2558

Application*: WB

Mouse Anti-IL18R1 Recombinant Antibody (17) (CBMAB-I0432-YY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 17

Application*: F

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I0717) (CBMAB-I1600-YY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0717

Application*: WB

Mouse Anti-IL18R1 Recombinant Antibody (70625) (CBMAB-I1601-YY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 70625

Application*: F, IH, N, IC, MC, I

Mouse Anti-IL18R1 Recombinant Antibody (B-E43) (CBMAB-I1994-YY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-E43

Application*: E, F, FN

Rat Anti-IL18R1 Recombinant Antibody (CBYY-I1266) (CBMAB-I2435-YY)

SDS

Target: IL18R1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-I1266

Application*: WB

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I1356) (CBMAB-I2526-YY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1356

Application*: IH, N, WB

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I1386) (CBMAB-I2556-YY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1386

Application*: E

Mouse Anti-IL18R1 Recombinant Antibody (CBYY-I1844) (CBMAB-I3014-YY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1844

Application*: F

Mouse Anti-IL18R1 (AA 20-329) Recombinant Antibody (CBFYC-2756) (CBMAB-C2831-FY)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-2756

Application*: F

Mouse Anti-IL18R1 Recombinant Antibody (H44) (CBMAB-C1760-CQ)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: H44

Application*: F

Mouse Anti-IL18R1 Recombinant Antibody (CBXC-0658) (CBMAB-C3211-CQ)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXC-0658

Application*: E

Mouse Anti-IL18R1 Recombinant Antibody (CBXC-0657) (CBMAB-C5350-CQ)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0657

Application*: F, WB

Mouse Anti-IL18R1 Recombinant Antibody (CBWJC-3808) (CBMAB-C5077WJ)

SDS

Target: IL18R1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-3808

Application*: FN

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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