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IL18R1

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq]
Full Name
interleukin 18 receptor 1
Function
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532).

Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).

Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Biological Process
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Interleukin-18-mediated signaling pathway Source: UniProtKB
Natural killer cell activation Source: Ensembl
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
Signal transduction Source: ProtInc
T-helper 1 cell differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 22-329
Helical: 330-350
Cytoplasmic: 351-541
PTM
N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.

Anti-IL18R1 antibodies

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Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 44G6
Application*: F
Target: IL18R1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C2558
Application*: WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 17
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0717
Application*: WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 70625
Application*: F, IH, N, IC, MC, I
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-E43
Application*: E, F, FN
Target: IL18R1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1266
Application*: WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1356
Application*: IH, N, WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1386
Application*: E
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1844
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2756
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: H44
Application*: F
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-0658
Application*: E
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0657
Application*: F, WB
Target: IL18R1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3808
Application*: FN
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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