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HSPB1

This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Full Name
heat shock protein family B (small) member 1
Alternative Names
CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102
Function
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975).

Plays a role in stress resistance and actin organization (PubMed:19166925).

Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).
Biological Process
Anterograde axonal protein transport Source: UniProtKB
Cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
Chaperone-mediated protein folding Source: UniProtKB
Intracellular signal transduction Source: BHF-UCL
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
Negative regulation of protein kinase activity Source: BHF-UCL
Platelet aggregation Source: UniProtKB
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
Positive regulation of endothelial cell chemotaxis Source: BHF-UCL
Positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of interleukin-1 beta production Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: BHF-UCL
Regulation of autophagy Source: ParkinsonsUK-UCL
Regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Regulation of protein phosphorylation Source: UniProtKB
Regulation of translational initiation Source: ProtInc
Response to unfolded protein Source: ProtInc
Response to virus Source: UniProtKB
Retina homeostasis Source: UniProtKB
Cellular Location
Cytoplasm; Spindle; Nucleus. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Involvement in disease
Charcot-Marie-Tooth disease 2F (CMT2F):
A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Onset of Charcot-Marie-Tooth disease type 2F is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later.
Neuronopathy, distal hereditary motor, 2B (HMN2B):
A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
PTM
Phosphorylated upon exposure to protein kinase C activators and heat shock (PubMed:8325890). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:8093612, PubMed:19166925).

Anti-HSPB1 antibodies

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Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Chicken
Clone: CBFYH-3377
Application*: E, IF, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Hamster
Clone: CBFYH-3322
Application*: WB, P, IF, IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2364
Application*: WB, C, P
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYH-2361
Application*: C, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-2360
Application*: E, IF, IP, PL, WB
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2357
Application*: WB, E, EC, IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2356
Application*: E, IF, P, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2355
Application*: WB, IC, P, C, E, IP, IF, F
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2354
Application*: F
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: CBFYH-2353
Application*: IH, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Dog, Cat, Goat, Fish, Human, Pig, Mouse, Rat
Clone: CBFYH-2351
Application*: E, IF, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2350
Application*: E, WB, P
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYH-2349
Application*: E, IC, IH, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2343
Application*: E, IC, C, P, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2341
Application*: E, WB, IF, IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2335
Application*: IC, IF, C, P, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2334
Application*: C, P, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYH-2333
Application*: WB, P, IF
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2331
Application*: WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2328
Application*: WB, P, IF
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle, Pig
Clone: CBFYH-2327
Application*: WB, IF
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Cattle, Rabbit, Mouse, Rat, Human
Clone: CBFYH-2326
Application*: WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2904
Application*: E, WB, IH, IC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2903
Application*: IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Rabbit
Clone: CBFYH-2902
Application*: WB, P, C, IC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: CBFYH-3250
Application*: P, C, IC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Dog, Cat, Goat, Fish, Human, Pig, Mouse, Rat
Clone: CBFYH-3247
Application*: E, IF, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: AF5E5
Application*: WB, IP, E
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F12-B10
Application*: P, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-3246
Application*: WB, E, ED, IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2345
Application*: IH, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2344
Application*: WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-3245
Application*: WB, IH, IF, IP, E
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Chicken, Sheep
Clone: CBFYH-3244
Application*: WB, F, P, IF, MC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey, Fish, Cattle
Clone: CBFYH-2342
Application*: E, IC, P, IP, WB, EM
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ACD5
Application*: IH
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2339
Application*: WB, IH, IF, IP, P
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Guinea pig, Hamster, Human, Mouse, Rat
Clone: CBFYH-2362
Application*: C, IF, IP, WB
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2359
Application*: F, IF
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2358
Application*: F, IF
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7BA18
Application*: WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7BA17
Application*: E
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7BA16
Application*: E, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7BA14
Application*: E, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EC169
Application*: WB, P
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: EG1582
Application*: WB, ICC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 5D7
Application*: WB, IHC, IF, FC, ELISA
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A324
Application*: IF, IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A323
Application*: IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A322
Application*: ELISA, IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: A321
Application*: ELISA, ICC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: A320
Application*: ICC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: A319
Application*: ICC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: A318
Application*: ICC, IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A317
Application*: IHC, IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Dog, Guinea pig, Hamster, Human, Mouse, Rat, Sheep
Clone: A316
Application*: ICC/IF, FC, FC, IHC, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A315
Application*: ICC/IF, ELISA, IHC, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A314
Application*: IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G3.1
Application*: ELISA, IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Pig
Clone: CAP901
Application*: ICC, IHC, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB483A
Application*: ELISA, WB, IHC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CB456A
Application*: ELISA, WB, ICC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SJ-5
Application*: ELISA, WB, IHC, ICC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB256
Application*: WB, IHC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H3
Application*: FC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb129
Application*: WB, IH
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: E1J4D
Application*: WB, IP, P
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D6W5V
Application*: WB, IP, IF (IC), F
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G3
Application*: WB, E
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 5D7-H1-A8
Application*: WB, IH, IC, F, IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 7E5-1F9-D9
Application*: WB, IC
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-149
Application*: E, WB, IH
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-148
Application*: E, WB, IH
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-076
Application*: E, WB, IH, IF, F, IP
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog, Rat
Clone: 6D435
Application*: E, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2T7
Application*: WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: JBW502
Application*: WB
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Cattle, Dog
Clone: D1H2F6
Application*: WB, P, IF, FC
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 41A8
Application*: E, IP, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Dog, Human, Mouse, Rat
Clone: 5B9
Application*: C, WB
Target: HSPB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 2079A
Application*: WB, IC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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