HOXA7

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.

homeobox A7

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Angiogenesis Source: UniProtKB
Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Negative regulation of cell-matrix adhesion Source: UniProtKB
Negative regulation of keratinocyte differentiation Source: MGI
Negative regulation of leukocyte migration Source: UniProtKB
Negative regulation of monocyte differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Stem cell differentiation Source: Ensembl

Nucleus