HEY2

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

hes related family bHLH transcription factor with YRPW motif 2

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

Anterior/posterior axis specification Source: Ensembl
Anterior/posterior pattern specification Source: GO_Central
Aortic valve morphogenesis Source: BHF-UCL
Arterial endothelial cell differentiation Source: BHF-UCL
Ascending aorta morphogenesis Source: BHF-UCL
Atrial septum morphogenesis Source: BHF-UCL
Cardiac conduction system development Source: BHF-UCL
Cardiac epithelial to mesenchymal transition Source: BHF-UCL
Cardiac left ventricle morphogenesis Source: BHF-UCL
Cardiac muscle hypertrophy in response to stress Source: Ensembl
Cardiac right ventricle morphogenesis Source: BHF-UCL
Cardiac septum morphogenesis Source: BHF-UCL
Cardiac vascular smooth muscle cell development Source: Ensembl
Cardiac ventricle morphogenesis Source: UniProtKB
Cell fate commitment Source: Ensembl
Circulatory system development Source: GO_Central
Cochlea development Source: Ensembl
Coronary vasculature morphogenesis Source: Ensembl
Dorsal aorta morphogenesis Source: BHF-UCL
Endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
Heart trabecula formation Source: Ensembl
Labyrinthine layer blood vessel development Source: BHF-UCL
Mesenchymal cell development Source: BHF-UCL
Muscular septum morphogenesis Source: BHF-UCL
Negative regulation of biomineral tissue development Source: BHF-UCL
Negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
Negative regulation of cardiac vascular smooth muscle cell differentiation Source: BHF-UCL
Negative regulation of gene expression Source: UniProtKB
Negative regulation of Notch signaling pathway Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
Negative regulation of transcription initiation from RNA polymerase II promoter Source: BHF-UCL
Negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
Notch signaling involved in heart development Source: BHF-UCL
Notch signaling pathway Source: UniProtKB
Outflow tract morphogenesis Source: BHF-UCL
Positive regulation of cardiac muscle cell proliferation Source: Ensembl
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of heart rate Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein-DNA complex assembly Source: Ensembl
Pulmonary artery morphogenesis Source: BHF-UCL
Pulmonary valve morphogenesis Source: BHF-UCL
Regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of vasculogenesis Source: BHF-UCL
Smooth muscle cell differentiation Source: BHF-UCL
Tricuspid valve formation Source: Ensembl
Tricuspid valve morphogenesis Source: BHF-UCL
Umbilical cord morphogenesis Source: BHF-UCL
Vascular associated smooth muscle cell development Source: UniProtKB
Vasculogenesis Source: BHF-UCL
Ventricular cardiac muscle cell development Source: UniProtKB
Ventricular septum morphogenesis Source: BHF-UCL
Ventricular trabecula myocardium morphogenesis Source: Ensembl

Nucleus