HCFC2

This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described.

Host Cell Factor C2

Chromatin remodeling Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Regulation of transcription by RNA polymerase II Source: ProtInc
Viral process Source: ProtInc

Cytoplasm; Nucleus