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GSTA1

This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Full Name

Glutathione S-Transferase Alpha 1

Function

Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911).

It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686).

Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).

Biological Process

Epithelial cell differentiation Source: UniProtKB
Glutathione derivative biosynthetic process Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Prostaglandin metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: GO_Central

Cellular Location

Cytoplasm

Anti-GSTA1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-GSTA1 Recombinant Antibody (CAP868) (CBMAB-AP2642LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CAP868

Application*: ICC, IHC, IP, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1999) (CBMAB-G5453-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBLG1-1999

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1998) (CBMAB-G5452-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-1998

Application*: E, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1995) (CBMAB-G5449-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: CBLG1-1995

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1993) (CBMAB-G5447-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1993

Application*: E

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1992) (CBMAB-G5446-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1992

Application*: E, IP, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1991) (CBMAB-G5445-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: S. japonicum

Clone: CBLG1-1991

Application*: E

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1989) (CBMAB-G5443-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Mouse

Clone: CBLG1-1989

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1986) (CBMAB-G5440-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1986

Application*: E, P, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1985) (CBMAB-G5439-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Mouse

Clone: CBLG1-1985

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1984) (CBMAB-G5438-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: S. japonicum

Clone: CBLG1-1984

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1981) (CBMAB-G5435-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: S. japonicum

Clone: CBLG1-1981

Application*: E

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1980) (CBMAB-G5434-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: CBLG1-1980

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1979) (CBMAB-G5433-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1979

Application*: E, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1978) (CBMAB-G5432-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1978

Application*: IC, C/P, E (IA), WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-1977) (CBMAB-G5431-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1977

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (3G10) (CBMAB-G5429-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3G10

Application*: IF, IH, IP, WB

Mouse Anti-GSTA1 Recombinant Antibody (38H11) (CBMAB-G5428-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 38H11

Application*: P

Mouse Anti-GSTA1 Recombinant Antibody (2-2) (CBMAB-G5427-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2-2

Application*: WB

Mouse Anti-GSTA1 Recombinant Antibody (13j40) (CBMAB-G5425-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 13j40

Application*: E, IH, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-261) (CBMAB-G0889-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: S. japonicum

Clone: CBLG1-261

Application*: IP, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-260) (CBMAB-G0888-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-260

Application*: E, WB

Mouse Anti-GSTA1 Recombinant Antibody (CBLG1-259) (CBMAB-G0887-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-259

Application*: E, IH, WB

Mouse Anti-GSTA1 Recombinant Antibody (286CT8.1.5) (CBMAB-G0884-LY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Mouse

Clone: 286CT8.1.5

Application*: WB

Mouse Anti-GSTA1 (AA 1-222) Recombinant Antibody (CBFYH-0518) (CBMAB-H1394-FY)

SDS

Target: GSTA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-0518

Application*: E, WB, IH

Mouse Anti-GSTA1 Recombinant Antibody (CBFYH-0517) (CBMAB-H1393-FY)

SDS

Target: GSTA1

Host: Mouse

Specificity: Human

Clone: CBFYH-0517

Application*: E, IC, IH, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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