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GRM1

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Full Name
glutamate metabotropic receptor 1
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890).

May function in the light response in the retina (By similarity).
Biological Process
Activation of MAPK activity Source: Ensembl
Activation of MAPKK activity Source: Ensembl
Cellular response to electrical stimulus Source: Ensembl
Chemical synaptic transmission Source: ProtInc
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
L-glutamate import across plasma membrane Source: Ensembl
Locomotory behavior Source: Ensembl
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: UniProtKB
Regulation of sensory perception of pain Source: Ensembl
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Sensory perception of pain Source: Ensembl
Cellular Location
Cell membrane
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, 13 (SCAR13):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR13 is characterized by delayed psychomotor development beginning in infancy. Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.
Spinocerebellar ataxia 44 (SCA44):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA44 is a slowly progressive, autosomal dominant form.
Topology
Extracellular: 19-592
Helical: 593-615
Cytoplasmic: 616-629
Helical: 630-650
Extracellular: 651-658
Helical: 659-680
Cytoplasmic: 681-703
Helical: 704-727
Extracellular: 728-750
Helical: 751-772
Cytoplasmic: 773-785
Helical: 786-807
Extracellular: 808-815
Helical: 816-840
Cytoplasmic: 841-1194

Anti-GRM1 antibodies

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Target: GRM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0130
Application*: WB
Target: GRM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYM-1107
Application*: P, C, WB
Target: GRM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1104
Application*: E, IH
Target: GRM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-1103
Application*: E, IH, WB
Target: GRM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: 20/mGluR1
Application*: WB, IF
Target: GRM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-0493
Application*: E, WB
Target: GRM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-1790
Application*: E, IH
Target: GRM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Pig
Clone: MEM-168
Application*: F
Target: GRM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2971
Application*: IC/IF, WB
Target: GRM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F7
Application*: E, WB
Target: GRM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: G209-488
Application*: WB
Target: GRM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G8
Application*: F
Target: GRM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1449
Application*: IHC: 1:50~1:100 ELISA: 1:5000
Target: GRM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D5H10
Application*: WB, IP, P, IF
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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