FOXP1

FOXP1 belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s).

Forkhead Box P1

Transcriptional repressor (PubMed:18347093, PubMed:26647308).

Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity).

Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity).

Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198).

Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093).

Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716).

Can negatively regulate androgen receptor signaling (PubMed:18640093).

Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735).
Isoform 8:
Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763).

Promotes ESC self-renewal and pluripotency (By similarity).

Cellular response to DNA damage stimulus Source: ARUK-UCL
Endothelial cell activation Source: UniProtKB
Macrophage activation Source: UniProtKB
Monocyte activation Source: UniProtKB
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of B cell apoptotic process Source: UniProtKB
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Osteoclast development Source: UniProtKB
Osteoclast differentiation Source: UniProtKB
Positive regulation of B cell receptor signaling pathway Source: ARUK-UCL
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of interleukin-21 production Source: UniProtKB
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Regulation of chemokine (C-X-C motif) ligand 2 production Source: UniProtKB
Regulation of defense response to bacterium Source: UniProtKB
Regulation of endothelial tube morphogenesis Source: UniProtKB
Regulation of gene expression Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Regulation of interleukin-12 production Source: UniProtKB
Regulation of interleukin-1 beta production Source: UniProtKB
Regulation of macrophage colony-stimulating factor production Source: UniProtKB
Regulation of monocyte differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of tumor necrosis factor production Source: UniProtKB
Response to lipopolysaccharide Source: UniProtKB
T follicular helper cell differentiation Source: UniProtKB

Nucleus. Not found in the nucleolus.

A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
Mental retardation with language impairment and autistic features (MRLIAF):
A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.