FN3K

A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]

Fructosamine 3 Kinase

Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663).

Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663).

Involved in intracellular deglycation in erythrocytes (PubMed:11975663).

Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity).

Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).

Epithelial cell differentiation Source: UniProtKB
Fructosamine metabolic process Source: GO_Central
Fructoselysine metabolic process Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein deglycation Source: UniProtKB

Cytosol