DTX1

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.

E3 ubiquitin-protein ligase DTX1

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Cell surface receptor signaling pathway Source: ProtInc
Cellular response to leukemia inhibitory factor Source: Ensembl
Glial cell differentiation Source: Ensembl
Negative regulation of neuron differentiation Source: UniProtKB
Negative regulation of T cell differentiation Source: Ensembl
Notch signaling pathway Source: GO_Central
Protein ubiquitination Source: GO_Central
Regulation of Notch signaling pathway Source: UniProtKB
Transcription, DNA-templated Source: UniProtKB
Transcription by RNA polymerase II Source: ProtInc

Nucleus; Cytoplasm. Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.

Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.