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DCX

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Full Name
Neuronal migration protein doublecortin
Function
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Biological Process
Axoneme assembly Source: GO_Central
Central nervous system development Source: ProtInc
Intracellular signal transduction Source: InterPro
Nervous system development Source: ProtInc
Neuron migration Source: UniProtKB
Photoreceptor cell development Source: GO_Central
Retina development in camera-type eye Source: GO_Central
Cellular Location
Cytoplasm; Neuron projection. Localizes at neurite tips.
Involvement in disease
Lissencephaly, X-linked 1 (LISX1):
A classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'.
Subcortical band heterotopia X-linked (SBHX):
SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.
PTM
Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity). Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity).
Ubiquitinated by MDM2, leading to its degradation by the proteasome. Ubiquitinated by MDM2 and subsequent degradation leads to reduce the dendritic spine density of olfactory bulb granule cells.

Anti-DCX antibodies

+ Filters
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Target: DCX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G5
Application*: P, IC, IF, WB, F, E
Target: DCX
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G12
Application*: E, IF, WB
Target: DCX
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D7E4
Application*: WB, IP
Target: DCX
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: IHC, WB
Target: DCX
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Y2C
Application*: IC, IF
Target: DCX
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Cattle, Pig
Clone: 3E1
Application*: IC, IF, WB
Target: DCX
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B218
Application*: E, F, IC, IH, WB
Target: DCX
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 13B814
Application*: IF, WB
Target: DCX
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B7
Application*: E
Target: DCX
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: A8L1U
Application*: IF
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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