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CSNK2A1

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq]
Full Name
CSNK2A1
Function
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621, PubMed:24962073).

Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:12631575, PubMed:19387552, PubMed:19387551).

May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387552, PubMed:19387551).

During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:11704824, PubMed:19188443).

Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis (PubMed:11239457).

Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:16193064).

Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:16193064).

Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551, PubMed:23123191).

Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550).

Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90 (PubMed:30699359).

Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549).

Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551).

During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:19387550, PubMed:12631575, PubMed:19387552, PubMed:19387551).

Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation (PubMed:20625391, PubMed:22406621).

Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (By similarity).

Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).
Biological Process
Apoptotic process Source: UniProtKB-KW
Chaperone-mediated protein folding Source: UniProtKB
Macroautophagy Source: Reactome
Mitotic chromosome condensation Source: Reactome
Negative regulation of apoptotic signaling pathway Source: ARUK-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic process Source: ARUK-UCL
Peptidyl-serine phosphorylation Source: UniProtKB
Peptidyl-threonine phosphorylation Source: CAFA
Phosphatidylcholine biosynthetic process Source: Reactome
Positive regulation of cell growth Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of protein catabolic process Source: UniProtKB
Positive regulation of Wnt signaling pathway Source: UniProtKB
Protein folding Source: Reactome
Protein phosphorylation Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of chromosome separation Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: Reactome
Rhythmic process Source: UniProtKB-KW
Signal transduction Source: ProtInc
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Nucleus
Involvement in disease
Okur-Chung neurodevelopmental syndrome (OCNDS):
An autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, behavioral problems, hypotonia, speech problems, microcephaly, pachygyria and variable dysmorphic features.
PTM
Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.

Anti-CSNK2A1 antibodies

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Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBCNC-407
Application*: E, WB, P
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-406
Application*: E, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 9H211
Application*: DB, IF, IH, IP, WB
Target: CSNK2A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 10F634
Application*: FC, IH, WB
Target: CSNK2A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJC-3239
Application*: WB, F, P
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-0588
Application*: E, P, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0589
Application*: DB, IC, IH, IP, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2863
Application*: WB, E
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Human, Monkey
Clone: CBYY-C2190
Application*: WB, IP, E, P, F, CI, IF
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Hamster, Human, Mouse, Rat
Clone: CBYY-C2189
Application*: E, IC, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: CBYY-C2188
Application*: WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0679
Application*: WB, IH, IC
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-2307
Application*: E, F, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2306
Application*: WB, P
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-2305
Application*: E, IH, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2304
Application*: E, IH, IP, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2303
Application*: WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYC-2302
Application*: F, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 8E5
Application*: CI, E, F, IP, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 844720
Application*: WB, IH, IC
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cattle, Hamster, Mouse, Rat
Clone: 6D210
Application*: E, C, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3D9
Application*: WB, IF
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 27H4
Application*: E, C, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1E1
Application*: C, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1AD9
Application*: WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 14e24
Application*: E, C, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 14e23
Application*: E, IH, IP, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B5
Application*: WB, P
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G1
Application*: E, WB
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Hamster, Rat
Clone: CBFYH-3399
Application*: WB, P
Target: CSNK2A1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16F5
Application*: E, M
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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