CERS4

CERS4 (Ceramide Synthase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS2.

Full Name

Ceramide Synthase 4

Function

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.

Biological Process

Ceramide biosynthetic process Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome

Cellular Location

Endoplasmic reticulum membrane

Topology

Lumenal: 1-31
Helical: 32-52
Helical: 140-160
Helical: 179-199
Helical: 209-229
Helical: 260-280
Helical: 304-324
Cytoplasmic: 325-394

PTM

Phosphorylated at the C-terminus by CK2.
N-glycosylated.

Anti-CERS4 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-CERS4 Recombinant Antibody (CBYJL-101) (CBMAB-L0157-YJ)

Datasheet

SDS

Target: CERS4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-101

Application*: E, WB

Mouse Anti-CERS4 Recombinant Antibody (CBYJL-100) (CBMAB-L0156-YJ)

Datasheet

SDS

Target: CERS4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-100

Application*: E, WB

Mouse Anti-CERS4 Recombinant Antibody (CBYJL-099) (CBMAB-L0155-YJ)

Datasheet

SDS

Target: CERS4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJL-099

Application*: WB, E

Mouse Anti-CERS4 Recombinant Antibody (CBYJL-097) (CBMAB-L0153-YJ)

Datasheet

SDS

Target: CERS4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJL-097

Application*: E, IF, WB

Mouse Anti-CERS4 Recombinant Antibody (CBYJL-095) (CBMAB-L0151-YJ)

Datasheet

SDS

Target: CERS4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJL-095

Application*: WB, IP, IF, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)