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CEACAM6

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 6
Function
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051).
Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051).
Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).
Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450).
Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051).
Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575).
Biological Process
Apoptotic process Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Leukocyte migration Source: Reactome
Negative regulation of anoikis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
Signal transduction Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane; Cell surface. Localized to the apical glycocalyx surface.
PTM
Glycosylated.
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Anti-CEACAM6 antibodies

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Mouse Anti-CEACAM6 Recombinant Antibody (CBXC-2708) (CBMAB-C0077-CQ)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBXC-2708
Application*: WB, F, E, IH
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBYY-C1857) (CBMAB-C3295-YY)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C1857
Application*: F, WB
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBYY-C1856) (CBMAB-C3294-YY)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C1856
Application*: F, IP
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBYY-C1855) (CBMAB-C3293-YY)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1855
Application*: F
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBYY-C1854) (CBMAB-C3292-YY)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1854
Application*: E, F
Datasheet SDS

Rabbit Anti-CEACAM6 Recombinant Antibody (CBYY-C1853) (CBMAB-C3291-YY)

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Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C1853
Application*: E
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBFYC-1689) (CBMAB-C1751-FY)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1689
Application*: E
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBFYC-0414) (CBMAB-C0457-FY)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYC-0414
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBFYC-0044) (CBMAB-C0051-FY)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0044
Application*: WB, IP, IF, P, F
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Rabbit Anti-CEACAM6 Recombinant Antibody (01) (CBMAB-C1576-LY)

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Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 01
Application*: E
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Rabbit Anti-CEACAM6 Recombinant Antibody (408) (CBMAB-C1264-LY)

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Target: CEACAM6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 408
Application*: E, F
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBT2231) (V2LY-0625-LY1695)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2231
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-CEACAM6 Recombinant Antibody (CBT2070) (V2LY-0625-LY1694)

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Target: CEACAM6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2070
Application*: IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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