CD70

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and protease binding.

Full Name

CD70 Molecule

Alternative Names

CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD70 Antigen; CD27 Ligand; CD27LG; TNFSF7; CD27-L;

Function

Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Biological Process

B cell mediated immunity Source: UniProtKB
B cell proliferation Source: UniProtKB
Cell-cell signaling Source: ProtInc
Extrinsic apoptotic signaling pathway Source: BHF-UCL
Positive regulation of T cell proliferation Source: GO_Central
Signal transduction Source: ProtInc
T cell mediated immunity Source: UniProtKB
Tumor necrosis factor-mediated signaling pathway Source: Reactome

Cellular Location

Membrane

Involvement in disease

Lymphoproliferative syndrome 3 (LPFS3): An autosomal recessive, early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus infection in B cells, abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have lymphadenopathy and hypogammaglobulinemia, and may suffer from recurrent infections.

Topology

Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-193

Anti-CD70 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-CD70 Recombinant Antibody (AG39) (V2LY-0524-LY114)

Datasheet

SDS

Target: CD70

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: AG39

Application*: B, E, F, IF

Rat Anti-CD70 Recombinant Antibody (AG38) (V2LY-0524-LY113)

Datasheet

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: AG38

Application*: F, In Vivo, WB

Rabbit Anti-CD70 Recombinant Antibody (EG547) (CBMAB-EN657-LY)

Datasheet

SDS

Target: CD70

Host: Rabbit

Antibody Isotype: IgG

Datasheet

SDS

Target: CD70

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYC-1411

Application*: E, N

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)